Genetic association studies: Is non-replication failure or progress?
نویسندگان
چکیده
منابع مشابه
When is a replication not a replication? Or how to spot a good genetic association study.
Published genetic association studies are becoming an epidemic. For example, whereas only 53 PubMed entries are found for the keywords “polymorphism” and “arthritis” in 1998, the number of entries is nearly 3-fold higher for 2004. With the recent completion of phase I of the haplotype map (HapMap) project and the continuing drop in genotyping costs, genome-wide association studies using up to 5...
متن کاملProgress in genetic association studies of plasma lipids
PURPOSE OF REVIEW This review summarizes recently published large-scale efforts elucidating the genetic architecture of lipid levels. A supplemental file with all genetic loci is provided for research purposes and we performed bioinformatic analyses of the genetic variants to give an oversight of involved pathways. RECENT FINDINGS In total, 52 genes for HDL cholesterol, 42 genes for LDL chole...
متن کاملNon-replication in Association Studies: ‘pseudo-failures’ to Replicate?
Recently, serious doubts have been cast on the usefulness of association studies as a means to genetically 'dissect' complex diseases, because most initial findings fail to replicate in subsequent studies. The reasons usually invoked are population stratification, genetic heterogeneity and inflated Type I errors. In this article, we argue that, even when these problems are addressed, the scient...
متن کاملFamilies or Unrelated: The Evolving Debate in Genetic Association Studies
To help uncover the genetic determinants of complex disease, a scientist often designs an association study using either unrelated subjects or family members within pedigrees. But which of these two subject recruitment paradigms is preferable? This editorial addresses the debate over the relative merits of family- and population-based genetic association studies. We begin by briefly recounting ...
متن کاملPathway analysis for genetic association studies: to do, or not to do? That is the question
In Genetic Analysis Workshop 18 data, we used a 3-stage approach to explore the benefits of pathway analysis in improving a model to predict 2 diastolic blood pressure phenotypes as a function of genetic variation. At stage 1, gene-based tests of association in family data of approximately 800 individuals found over 600 genes associated at p<0.05 for each phenotype. At stage 2, networks and enr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery
سال: 2019
ISSN: 0022-5223
DOI: 10.1016/j.jtcvs.2019.02.025